It was an honor to have Dr. Dominc D'Agostino on our podcast since he was the one who inspired us to start Ketogeek in the first place when we first heard him at Tim Ferriss's podcast. We have always looked up to him as a role model when it comes to researching, asking questions and consistently learning while at the same time helping educate the public.
Bio: Dr. Dominic D’Agostino is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). His laboratory develops and tests nutritional strategies and metabolic-based supplements for neurological disorders, cancer and performance. He was a crew member on NASA’s Extreme Environment Mission Operations 22 (NEEMO 22) and has a personal interest in environmental medicine and methods to enhance safety and physiological resilience in extreme environments. His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations.
3:36 - New in Dr. Dominic’s life and latest research going on
5:39 - Hyperbaric vs. Hypobaric & countermeasures against extreme environments
11:55 - Hyperbaric Oxygen Therapy and its various applications
13:54 – Biological mechanism behind Hyperbaric Oxygen Therapy for combating cancer
20:34 – How to determine frequency and pressure for Hyperbaric Oxygen Chamber?
21:52 – How to design a Ketogenic diet to be used for experimentation?
24:09 - Impact of Ketogenic diet in rodent models
27:00 – Comprehensive protocols and therapy designs to combat cancer
28:40 – How to take animal models and apply them to human therapy and clinical trials?
32:40 – Can computer models and machine learning help with simulating the growth of cancerous cells?
36:12 – Warburg Effect, metabolic approach and is there a relationship between genetics and cancer?
43:17 – Steps to take if I have cancer?
50:49 – Resources available from Dr. Dominic and promoting the role of nutrition and modern cancer therapies.
57:16 – Overcoming challenges when pushing paradigm shifting ideas in the world
1:00:06 – Inflammation and signaling effects of Ketones
1:03:25 – Tracking the right biomarkers to maximize the potency of a therapeutic ketogenic diet
1:09:48 – How NEEMO 22 (NASA Extreme Environment Mission Operations) simulates an extreme environment.
1:13:10 – Objectives carried out and biomarkers tracked during this operation
1:15:13 – Pitching the Ketogenic Diet against the NEEMO environment
1:16:00 – Routines, tasks and gadgets used to gather data for various researches
1:20:31 – Impact of NEEMO environment on inflammation, stress levels, sleep and task loading
1:22:14 – Objective prioritization and efficient multi-tasking in the extreme aquatic environment
1:27:54 – Dr. Dominic’s plug and recommendations
Social Media accounts (Twitter/Instagram/SnapChat/Facebook):
Academia (research pubs): https://usf.academia.edu/DominicDAgostino
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